Mu-conotoxin

Conotoxin is a highly folded peptide with strong penetration, high stability, and targeted muscle relaxation. By blocking the current conduction of nerves and muscles, wrinkles are instantly diminished, and the skin rejuvenates and looks younger by peptide cosmetic ingredients.

Mu-conotoxins block voltage-gated sodium channels (Nav). This synthetic toxin blocks both voltage-gated sodium channels and nicotinic acetylcholine receptor (nAChR). Inhibits the skeletal muscle rNav1.4/SCN4A (IC50=1.3 nM) and the brain rNav1.2/SCN2A in a long-lasting manner. A low inhibition is also observed on neuronal mNav1.6/SCN8A and mNav1.7/SCN9A. Modestly blocks nAChR alpha-3/beta-2 subtype (IC50=450 nM) (partially reversible) and, to a lesser extent, alpha-7 and alpha-4/beta-2 subtypes (reversible). In vitro, decreases twitch tension in mouse hemidiaphragms (IC50=150 nM), and displays a high blocking effect in mouse extensor digitorum longus muscles (IC50=46 nM).

Synonym

mu-conotoxin; XEP-018; CONOTOXIN; ACETYTETRAPEPTIDE-9; ConoAntiwrinkle; L-Cysteinamide, 5-oxo-L-prolylglycyl-L-cysteinyl-L-cysteinyl-L-asparaginylglycyl-L-prolyl-L-lysylglycyl-L-cysteinyl-L-seryl-L-seChemicalbookryl-L-lysyl-L-tryptophyl-L-cysteinyl-L-arginyl-L-α-aspartyl-L-histidyl-L-alanyl-L-arginyl-L-cysteinyl-, cyclic(3→15), (4→21), (10→22)-tris(disulfide); Conotoxin/Conopeptide/CTX

• CAS No.: 936616-33-0

• EC No.: 606-757-9

• MF: C92H139N35O28S6

• MW: 2375.7